The drive to optimize every aspect of the modern commercial and industrial building is not new. Mechanical thermostats have been replaced with comprehensive environmental monitoring systems, networked and connected to IT-style backends and much more. We are still at the beginning of these changes: the need to create an energy/materials-efficient, productive, enjoyable, and safe environment is an incredible challenge, demanding truly transformative technology ingredients integrated into a complex connected system. This white paper explores the major challenges and transformative technologies addressing focus areas such as operator enhancing interfaces, cloud and mesh connected devices, and enhanced controls.