Air conditioners utilizing Thermoelectric Modules (TEMs) are often considered as an alternative to conventional vaporcompression systems for enclosure cooling. Because a TEM is compact, robust, and completely solid-state, the inherent reliability of such a system is attractive to engineers and end-users alike. However, there is an inherent reluctance to choose a thermoelectric-based system due to preconceptions about energy efficiency or lack of experience with thermoelectrics. This paper compares and contrasts two cooling technologies. Comparisons of efficiency, reliability, control, as well as installation and maintenance, demonstrate that a thermoelectric based solution can have significant advantages over conventional compressor based systems.