This paper outlines the processes and methodologies which have been successfully developed and utilized by Intel and TRIL researchers in the design, implementation, deployment, management, and analysis of home and community based research pilots. Translation of research from the confines of the laboratory to real world environments of community clinics and people’s homes is challenging. However, when successful it can deliver meaningful benefits to both patients and clinicians. A number of case studies are presented in this article to illustrate how the processes and methodologies have been applied by Intel and the TRIL Centre to the successful deliver sensor based research applications in community and home based settings.