This application note discusses the core of modern advanced electronics, which is typically a microcontroller that communicates with one or more peripheral devices that were originally memory mapped and connected to the data and address bus. However, due to high pin count, increased package size, and overall cost, another connection/communication scheme became the dominant choice—the serial interface. This article compares different serial interfaces, such as 1-Wire, SPI, I2C, USB, etc., with respect to physical network size, network drivers, power supply, data rate, network inventory, and choice of functions. It shows how competitive and innovative the 1-Wire serial interface can be to the engineer trying to decide which serial interface to select.