Although there is continued effort in the semiconductor packaging industry to reduce package size along with the never ending pursuit of cost savings, there remain a significant number of applications which require a wildly different set of capabilities for wire bonding. This paper will explore the wire bonding requirements of several device cases that could be considered odd form factor package formats when compared to mainstream semiconductor packaging. Example cases are presented to show the challenges and solutions to wire bond packages in the RF, Automotive, and Optical markets with large form factor (12inch x 6inch), deep reach (0.535 inch), leads, pins, and other challenges.