This paper reports on a single-chip wireless IC that is capable of time-share measurement of chemical and electrical neural activity at the same recording site in vivo. By taking advantage of the discontinuous sampling of fast-scan cyclic voltammetry (FSCV) and performing EPHYS in-between successive FSCV scans, this is the first chip that enables chemically resolved monitoring of extracellular dopamine and its postsynaptic effect in the same time and microscopic locale. Dopamine underlies cognition and motivation, and is intimately involved in the neuropathologies of Parkinson’s disease and drug abuse.