Application software lies at the core of modern data acquisition (DAQ) systems, making it imperative that you select a software tool that fits the needs of your application today and easily scales as your system matures. The last thing you want to do is rewrite all of your code using new application software simply because your old code got too unwieldy to expand. Determining trade-offs to make when selecting the best application software tool for your DAQ system depends on the requirements that need to be met. This paper walks through five questions to consider when choosing your application software.