TMS320F28xx and F28xxx digital signal controllers (DSCs) include multiple complex peripherals running at fairly high-clock frequencies. They are commonly connected to low level analog signals using an on-board analog-to-digital converter (ADC). This application report is organized as a guide for system level hardware design, parts selection, and schematics design to board layout and helps in avoiding those hardware errors that become costly and time consuming when detected during the system level-debugging phase of the project, using the prototype of the custom board of the project.