The availability of devices incorporating hardened ARM applications processors closely coupled to an on-chip FPGA fabric opens a world of possibilities to electronic system designers. However, these devices also introduce novel design, debug, and optimization challenges. New development methodologies are required to address software and hardware integration issues and system-level performance optimizations efficiently at a price affordable by small- and medium-sized companies. This white paper outlines Altera and ARM’s latest innovations in on-chip debug logic, FPGAs, and software debug and analysis tools aimed to address these challenges.