This paper provides a road map for how to navigate prototype bring-up tasks using the Synopsys HAPS Developer eXpress (HAPS-DX) system. The combination of the methodology described by the FPGA-Based Prototyping Methodology Manual and the design automation software features provided with HAPS-DX can improve productivity and reduce the processing time required to implement ASIC RTL and IP into the FPGA and other hardware resources of the prototyping system.