This paper discusses the potential of electronically conducting polymer sensors for interfacing high-performance integrated circuits to the chemical and biological worlds. The paper shows why bulk crystalline semiconductors are not really suited for sensors for detecting molecules. It then goes on to qualitatively introduce conducting polymers and show how devices made using conducting polymers satisfy to a considerable extent the functional requirements of sensors for chemicals. The paper concludes with a quick discussion of molecular ion-sensitive FETs, enzyme FETs, and enzyme-linked immunosorbent sensors.