The availability of powerful I2C buffers that drive I/Os on both sides to a nominal ground or ‘zero offset’ logic level allows the removal of noise introduced into one section of a larger bus system. That ‘regeneration’ of clean I2C signals enables building long I2C-buses by combining together relatively short bus sections. Conventional twisted pair communication cabling with its convenient connectors and a modular I2C system approach, make large system assembly easy. Each drop point or node can be individually selected for bidirectional data communication with the Master just by using normal I2C software addressing. As an example, this paper describes a system for control of LED lighting displays.