Bio-patch solutions are poised to revolutionize the health and fitness market and create new ways of providing healthcare both in clinical and remote settings. The wearable sensor enables patient safety and comfort in clinical settings and provides for long-term diagnostic monitoring while the individual participates in daily activities. For the athlete, the bio-patch provides an alternative to bands that suffer from noise artifacts such as motion and light. Given the unobtrusive and small form factor requirements of the bio-patch, optimizing power efficiency becomes highly critical in order to extend the lifetime and effectiveness of the application.