Multiple Device Synchronization (MDS) in Analog-to-Digital Converters enables multiple ADC device digital output streams (up to 16 channels) to be sample-level synchronized and phase coherent. There are many high-speed digital signal processing applications in which data acquisition sample synchronization is desirable or required. These include OFDM digital radio, synthetic beamforming radar, automatic integrated circuit test, precision quadrature instrumentation, and high-definition video broadcast equipment. This white paper provides a simplified theory of operation to introduce ADC-based MDS to the mixed-signal design engineering community. This easy-to-use feature saves precious design time and reduces system bill of materials costs.