As high-speed I/O (HSIO) and serial link data rates keep increasing, the requirements for accuracy and advanced modeling and simulation techniques have become more demanding. This white paper reviews the techniques used in recent HSIO simulation and modeling, including their limitations. It then introduces Altera’s JNEye link analysis tool, a tool that enhances HSIO link modeling and simulation through two new methods—full waveform and hybrid simulation. This paper also includes simulation and experimental results that demonstrate how the JNEye tool can meet emerging requirements.